Treatment of Suspected Hyper-Reactive Malarial Splenomegaly (HMS) in Pregnancy with Mefloquine
Title | Treatment of Suspected Hyper-Reactive Malarial Splenomegaly (HMS) in Pregnancy with Mefloquine |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Jaroensuk, J, Stoesser, N, Leimanis, ML, Jittamala, P, White, NJ, Nosten, F, McGready, R |
Journal | The American Journal of Tropical Medicine and Hygiene |
Date Published | March 3, 2014 |
Abstract | Malaria infections in pregnancy are associated with adverse outcomes for both mother and child. There are few data on hyper-reactive malarial splenomegaly, an aberrant immunological response to chronic or recurrent malaria in pregnancy. This retrospective assessment reviewed the impact of mefloquine treatment on pregnant women with suspected hyper-reactive malarial splenomegaly in an area of low malaria transmission in the 1990s, showing significant reductions in spleen size and anemia and anti-malarial antibody titers without any notable negative effect on treated women or their newborns. |
URL | http://www.ajtmh.org/content/90/4/609.full.pdf |