Strict tropism for CD71+/CD234+ human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi
Title | Strict tropism for CD71+/CD234+ human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Kosaisavee, V, Suwanarusk, R, Chua, ACY, Kyle, DE, Malleret, B, Zhang, R, Imwong, M, Imerbsin, R, Ubalee, R, Sámano-Sánchez, H, Yeung, BKS, Ong, JJY, Lombardini, E, Nosten, F, Tan, KSW, Bifani, P, Snounou, G, Renia, L, Russell, B |
Journal | Blood |
Volume | 130 |
Issue | 11 |
Pagination | 1357-1363 |
Date Published | 2017 |
Abstract | Zoonotic P cynomolgi switches red cell tropism for reticulocytes expressing Trf1 (CD71+) and DARC (CD234+).In the human host, P cynomolgi displays an almost identical rheopathobiology to P vivax.Two malaria parasites of Southeast Asian macaques, Plasmodium knowlesi and P cynomolgi, can infect humans experimentally. In Malaysia, where both species are common, zoonotic knowlesi malaria has recently become dominant, and cases are recorded throughout the region. By contrast, to date, only a single case of naturally acquired P cynomolgi has been found in humans. In this study, we show that whereas P cynomolgi merozoites invade monkey red blood cells indiscriminately in vitro, in humans, they are restricted to reticulocytes expressing both transferrin receptor 1 (Trf1 or CD71) and the Duffy antigen/chemokine receptor (DARC or CD234). This likely contributes to the paucity of detectable zoonotic cynomolgi malaria. We further describe postinvasion morphologic and rheologic alterations in P cynomolgi–infected human reticulocytes that are strikingly similar to those observed for P vivax. These observations stress the value of P cynomolgi as a model in the development of blood stage vaccines against vivax malaria. |
URL | http://www.bloodjournal.org/content/bloodjournal/130/11/1357.full.pdf |