Plasmodium falciparum genetic crosses in a humanized mouse model
| Title | Plasmodium falciparum genetic crosses in a humanized mouse model |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Vaughan, AM, Pinapati, RS, Cheeseman, IH, Camargo, N, Fishbaugher, M, Checkley, LA, Nair, S, Hutyra, CA, Nosten, F, Anderson, TJ, Ferdig, MT, Kappe, SH |
| Journal | Nat Methods |
| Volume | 12 |
| Issue | 7 |
| Pagination | 631-3 |
| Date Published | Jul |
| ISBN Number | 1548-7105 (Electronic)1548-7091 (Linking) |
| Abstract | Genetic crosses of phenotypically distinct strains of the human malaria parasite Plasmodium falciparum are a powerful tool for identifying genes controlling drug resistance and other key phenotypes. Previous studies relied on the isolation of recombinant parasites from splenectomized chimpanzees, a research avenue that is no longer available. Here we demonstrate that human-liver chimeric mice support recovery of recombinant progeny for the identification of genetic determinants of parasite traits and adaptations. |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/26030447 |
| Short Title | Nature methods |
