Molecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand

TitleMolecular Markers and In Vitro Susceptibility to Doxycycline in Plasmodium falciparum Isolates from Thailand
Publication TypeJournal Article
Year of Publication2015
AuthorsGaillard, T, Sriprawat, K, Briolant, S, Wangsing, C, Wurtz, N, Baragatti, M, Lavina, M, Pascual, A, Nosten, F, Pradines, B
JournalAntimicrob Agents Chemother
Date PublishedJun 8
ISBN Number1098-6596 (Electronic)0066-4804 (Linking)
Abstract

Doxycycline IC50 determinations of 620 isolates from Northwest Thailand were performed via the isotopic method and analysed by Bayesian method and distributed into two populations (mean IC50 of 13.15 muM and 31.60 muM). There was no significant difference between the group with low IC50 versus the group with high IC50 with regards to copy numbers of pftetQ gene (P = 0.11) or pfmdt gene (P = 0.87) or PfTetQ KYNNNN repeats (P = 0.72).

URLhttp://www.ncbi.nlm.nih.gov/pubmed/26055380
Short TitleAntimicrobial agents and chemotherapy